Too LITTLE or Too MUCH: Addison’s vs. Cushing’s Disease in Dogs

In this episode, Marty and Laura dive into two often-confused but fundamentally opposite adrenal diseases in dogs: Addison’s disease (hypoadrenocorticism) and Cushing’s disease (hyperadrenocorticism). While both involve the adrenal glands, one is caused by too little hormone production and the other by too much.

Marty explains the anatomy and function of the adrenal glands, how these diseases present very differently in real life, and why they can be so challenging to diagnose and manage. The conversation also addresses common misconceptions around genetics and breeding, emphasizing that even dogs from excellent breeding programs can develop these conditions. With real-world examples, including Laura’s own dogs, the episode highlights symptoms to watch for, diagnostic challenges, treatment options, long-term prognosis, and why careful veterinary monitoring is essential.

The discussion expands into related conditions like diabetes and kidney disease, underscoring an important message: similar symptoms can point to very different underlying problems, and accurate diagnosis matters.

5 Key Takeaways

1. Addison’s and Cushing’s Are Opposites — But Equally Serious

Addison’s disease occurs when the adrenal glands don’t produce enough hormones, often causing sudden, severe illness. Cushing’s disease is caused by excess cortisol and develops slowly over months or even years. Despite affecting the same body system, they look and behave very differently.

2. You Can’t Always “Breed Away” From These Diseases

While some breeds (like Poodles and Nova Scotia Duck Tolling Retrievers) show higher incidence, there is no universal genetic test for Addison’s or Cushing’s. Even carefully bred dogs from responsible programs can develop them, making transparency and education more important than blame.

3. Symptoms Can Be Subtle — Until They Aren’t

Addison’s often presents as waxing-and-waning illness, GI upset, lethargy, or sudden collapse. Cushing’s is more insidious, with signs like excessive drinking and urination, pot-bellied appearance, and gradual decline. Early signs are easy to miss or mistake for aging or other diseases.

4. Diagnosis and Management Are Tricky and Ongoing

Testing for both conditions can be complex and sometimes inconclusive. Management requires lifelong medication, frequent blood work, and close veterinary supervision. While both diseases are treatable, they demand commitment from owners and strong communication with the veterinary team.

5. PU/PD Isn’t Just One Disease

Excessive drinking and urination (PU/PD) can signal many different conditions, including diabetes, kidney disease, infections, or adrenal disorders. Similar symptoms don’t mean the same diagnosis — which is why thorough diagnostics are critical to getting treatment right.

The Marty & Laura Show is produced by Pure Dog Talk Inc., with sound design and editing by Premium Audio Services.

Five Tips for Fun, Safe Holidays with Pets

Marty and Laura offer up five pro tips for a fun and safe holiday with pets. Sidenote, keep your eyes peeled for Marty during the National Dog Show on NBC at noon Thanksgiving Day.

Tip 1… Canned pumpkin, which may well be not entirely pumpkin, is great for dogs and cats! Give them a tablespoon in their food *before* you make the pie.

Tip 2 … Making soup stock from the turkey carcass? Save the cooked veggies for the dog’s dinner so they can join the celebration.

Tip 3 … The microwave is a GREAT food locker to keep the four-legged family out of the food when you turn your back.

Tip 4 … Save a few bucks on fun pet food toppers by looking for “windfall” apples for homemade applesauce, inquiring with your grocery store for bruised produce or checking out online delivery resources like Imperfect Foods.

Tip 5 … Make a batch of *dog* cookies with your holiday baking.

Ingredients

• 2 cups whole wheat flour (regular white flour will work as well) 
• 1 cup canned pureed pumpkin (don’t use pumpkin pie filling, as it includes additional sugar, fats, and spices like cinnamon that are dangerous to your dog)
• 1/2 cup peanut butter (make sure it doesn’t contain artificial sweeteners like xylitol)

Directions

• Preheat your oven to 375°F.
• Add the pumpkin and peanut butter to a large mixing bowl and stir to combine.
• Stir in the flour until the mixture creates a dough.
• Roll out the dough about ½ inch thick on a lightly floured surface.
• Cut out fall shapes using a small cookie cutter or knife. Bonus points if you use a fall-themed cookie cutter in a pumpkin shape. 
• Place the treats about half an inch apart on an ungreased cookie sheet.
• Bake for 12 minutes.
• Let cool completely before giving to your dog to enjoy.

Bone-Appetit!

Recipe inspired by the American Kennel Club. This article contains recipe information that is considered suitable for pets. However, not all pets can tolerate different foods — it depends on their age, health history, and health conditions. It is important to consult with your veterinarian before feeding your pet any new foods or offering your pet any of the ingredients contained in this recipe.

The Marty & Laura Show is produced by Pure Dog Talk Inc., with sound design and editing by Premium Audio Services.

Giving Thanks for the Pets in Our Lives

Marty and Laura kick off a month of giving thanks for the pets in our lives. Our animals brighten our days, bring us together with friends, provide companionship and comfort year round. So we decided to celebrate that special connection throughout November.

Since November is the month of giving, we’re also highlighting a different organization dedicated to animals and the people who love them each week. This week Marty shares information about her own non-profit, Pink Paw, which seeks to raise awareness of breast cancer in our pets and funds for desperately needed new research.

And we’re starting this conversation about our special relationships with our pets with a really fascinating deep dive into the ethical, moral and legal ramifications of language around our pets. Terms like “fur baby” and “pet parent” can have serious long-term unintended consequences.

“There has to be somewhere in the middle that we have a being that’s alive that’s different than your toaster, but is technically not a human, so it’s not part of your family,” Marty noted, putting on her lawyer hat. “There’s been all kinds of cases that people have tried to bring creatures into the category of humans, and we have to be really careful as a society. Because if we cross that line, we’re going to end up with some very serious issues.

“If the dog equals a human and you need to put your dog down for behavioral euthanasia, for example, now are we committing murder?”

Tap in to join Marty and Laura as they tackle these and other huge questions around our unique and important relationships with our pets. Like and share with friends and family!

The Marty & Laura Show is produced by Pure Dog Talk Inc., with sound design and editing by Premium Audio Services.

“Howloween”: Costumes and Doorbells and Chocolates, Oh MY!

Marty and Laura are joined by Glinda the Good Witch to talk about Halloween and the fun, as well as potential pitfalls, for our pets.

“Everybody wants to address their pet up in a cute little costume,” Marty noted. “And you know, some of them are fine and the pets are comfortable in them and they’re not scary and they’re really cute. And sometimes we’re expecting just a little too much of our pets, depending on the pet and what they like.

“We have to respect there are some pets that are happy to wear clothing. And they’re cute and they are comfortable in it and it’s adorable. And then there are pets who are not, especially if it covers their head or it makes weird noises or it’s crinkly or it’s weird or anything.

“And so you have to really be thinking about whether this makes your pet comfortable or uncomfortable. And if they’re not comfortable in it, don’t scare them. Put it on like for two seconds. Get a quick picture, put it on Facebook and then put the costume away. Your pet will tell you.

“If you’re expecting your pet to be part of the group that goes trick or treating, then get them used to the costumes in advance so that they know what you’re going to look like. Usually if you’re wearing something over your face or on your head, it changes your profile and your pet really identifies a lot, not by looking just at your face, but how you look in profile.

“You have to acclimate them so that they’re comfortable with that kind of situation if you’re expecting them to go skipping down the street with them on a leash while you’re taking the kids trick or treating. They’re gonna see other strange creatures and zombies and you know, I think it’s really important to have realistic expectations of our pets.”

The Marty & Laura Show is produced by Pure Dog Talk Inc., with sound design and editing by Premium Audio Services.